Search results for "Type A"
showing 10 items of 111 documents
F-contractions of Hardy–Rogers-type and application to multistage decision
2016
We prove fixed point theorems for F-contractions of Hardy–Rogers type involving self-mappings defined on metric spaces and ordered metric spaces. An example and an application to multistage decision processes are given to show the usability of the obtained theorems.
Occurrence of organic-matter-rich beds in Early Cretaceous coastal evaporitic setting (Dorset, UK): a link to long-term palaeoclimate changes?
2009
11 pages; International audience; In Dorset (southern U.K.), the Durlston Bay and Lulworth Cove sections expose lowermost Cretaceous coastal marine and non-marine partly evaporitic sediments (the so-called Purbeckian facies). An interval with organic matter (OM)-rich layers is recognized in both sections. This OM-rich interval is 20 m thick in the middle of the Durlston Bay section. Within these beds, a large OM accumulation is recorded, with total organic carbon (TOC) of up to 8.5 wt%. High hydrogen index (HI) values (up to 956 mgHC/gTOC) point to a Type I OM, generally considered as derived from algal-bacterial biomass. This contrasts with the OM present in the underlying and overlying in…
Distribution of late Maastrichtian pachydiscid and scaphitid ammonites in the Maastricht and Kunrade formations of the southeast Netherlands
2018
Abstract The pachydiscid Pachydiscus ( Pachydiscus ) gollevillensis (d'Orbigny, 1850), long held to be confined to the ‘Kunrade Limestone’ (nowadays Kunrade Formation) in the eastern part of southern Limburg (Kunrade–Benzenrade area, the Netherlands), is now recorded from the basal Nekum Member (Maastricht Formation) at the ENCI-HeidelbergCement Group quarry, Sint-Pietersberg (Maastricht). Here we review the stratigraphic distribution of pachydiscid and scaphitid ammonites in outcrops west of the River Maas (Maastricht Formation) and in the Kunrade–Benzenrade area (Kunrade Formation). The latter unit has been correlated with part of the Lanaye Member (Gulpen Formation) up to the basal Emael…
A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem ce…
2016
AbstractHutchinson-Gilford progeria syndrome (HGPS) is a rare fatal genetic disorder that causes systemic accelerated aging in children. Thanks to the pluripotency and self-renewal properties of induced pluripotent stem cells (iPSC), HGPS iPSC-based modeling opens up the possibility of access to different relevant cell types for pharmacological approaches. In this study, 2800 small molecules were explored using high-throughput screening, looking for compounds that could potentially reduce the alkaline phosphatase activity of HGPS mesenchymal stem cells (MSCs) committed into osteogenic differentiation. Results revealed seven compounds that normalized the osteogenic differentiation process an…
Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
2019
Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction and premature entry into cellular senescence. Recently, we reported that telomere dysfunction induces the transcription of telomeric non-coding RNAs (tncRNAs) which control the DNA damage response (DDR) at dysfunctional telomeres. Here we show that progerin-induced telomere dysfunction induces the transcription of tncRNAs. Their functional inhibition by sequence-specific telomer…
Consensus recommendation for a diagnostic guideline for acid sphingomyelinase deficiency
2017
Disclaimer: This diagnostic guideline is intended as an educational resource and represents the opinions of the authors, and is not representative of recommendations or policy of the American College of Medical Genetics and Genomics (ACMG). The information should be considered a consensus based on expert opinion, as more comprehensive levels of evidence were not available in the literature in all cases. Background: Acid sphingomyelinase deficiency (ASMD) is a rare, progressive, and often fatal lysosomal storage disease. The underlying metabolic defect is deficiency of the enzyme acid sphingomyelinase that results in progressive accumulation of sphingomyelin in target tissues. ASMD manifests…
Dopamine, Noradrenaline and Serotonin Receptor Densities in the Striatum of Hemiparkinsonian Rats following Botulinum Neurotoxin-A Injection.
2017
Abstract Parkinson’s disease (PD) is characterized by a degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) that causes a dopamine (DA) deficit in the caudate-putamen (CPu) accompanied by compensatory changes in other neurotransmitter systems. These changes result in severe motor and non-motor symptoms. To disclose the role of various receptor binding sites for DA, noradrenaline, and serotonin in the hemiparkinsonian (hemi-PD) rat model induced by unilateral 6-hydroxydopamine (6-OHDA) injection, the densities of D1, D2/D3, α1, α2, and 5HT2A receptors were longitudinally visualized and measured in the CPu of hemi-PD rats by quantitative in vitro receptor autorad…
An Integrated Pharmacophore/Docking/3D-QSAR Approach to Screening a Large Library of Products in Search of Future Botulinum Neurotoxin A Inhibitors
2020
Botulinum toxins are neurotoxins produced by Clostridium botulinum. This toxin can be lethal for humans as a cause of botulism
Sng1 associates with Nce102 to regulate the yeast Pkh–Ypk signalling module in response to sphingolipid status
2016
International audience; All cells are delimited by biological membranes, which are consequently a primary target of stress-induced damage. Cold alters membrane functionality by decreasing lipid fluidity and the activity of membrane proteins. In Saccharomyces cerevisiae, evidence links sphingolipid homeostasis and membrane phospholipid asymmetry to the activity of the Ypk1/2 proteins, the yeast orthologous of the mammalian SGK1-3 kinases. Their regulation is mediated by different protein kinases, including the PDK1 orthologous Pkh1/2p, and requires the function of protein effectors, among them Nce102p, a component of the sphingolipid sensor machinery. Nevertheless, the mechanisms and the act…
Pulmonary Adenocarcinoma With Enteric Differentiation: Immunohistochemistry and Molecular Morphology
2018
Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare subtype of lung adenocarcinoma recently recognized in the WHO classification. It is defined as an adenocarcinoma in which the enteric component exceeds 50% and have to show the expression of at least 1 immunohistochemical marker of enteric differentiation. Although the definition of this tumor type is very important, above all in the differential diagnosis between a primary lung tumor and a metastasis of colorectal adenocarcinoma, this cancer still lacks a distinctive immunohistochemical and molecular signature. We recruited the largest series in the literature of PAEDs according to the morphology and the positivity for …